Evidence supporting the use of: Vitamin B6
For the health condition: PMS (general)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is commonly used to support or treat symptoms of premenstrual syndrome (PMS). There is some scientific evidence supporting its use, though the quality and consistency of the data are moderate, not strong. Several randomized controlled trials and systematic reviews have investigated vitamin B6 supplementation (typically in doses of 50-100 mg/day) for PMS symptoms such as mood changes, irritability, and breast tenderness. A meta-analysis published in the British Journal of Obstetrics and Gynaecology (Wyatt et al., 1999) found that vitamin B6 was more effective than placebo in relieving overall PMS symptoms, particularly emotional symptoms, though the effect size was modest and some studies included in the review had methodological limitations.

The rationale for using vitamin B6 stems from its role in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation. Some women with PMS may have altered neurotransmitter metabolism, and B6 could potentially help correct this imbalance. However, more recent reviews (e.g., Cochrane Database, 2019) conclude that while there is some benefit, the evidence is not robust, and further high-quality trials are needed to confirm efficacy and safety. Vitamin B6 is generally safe at recommended doses, but chronic high intake can cause neuropathy.

In summary, the use of vitamin B6 for PMS is supported by moderate scientific evidence, particularly for mood-related symptoms, but it is not considered a definitive or first-line treatment.

More about vitamin B6
More about PMS (general)

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave