Evidence supporting the use of: Squaw Vine
For the health condition: PMS (general)
Synopsis
Source of validity: Traditional
Rating (out of 5): 1
Squaw Vine (Mitchella repens) has a long history of use in traditional herbal medicine, particularly among Native American communities and early American herbalists. It is most commonly associated with women’s reproductive health, especially as a uterine tonic to prepare for childbirth. Its use for premenstrual syndrome (PMS) is primarily rooted in tradition rather than scientific research. Historical herbal texts, such as those by eclectic physicians in the 19th and early 20th centuries, mention Squaw Vine as a remedy for menstrual difficulties, cramps, and general female complaints. However, there are no well-designed clinical trials or robust pharmacological studies to validate these claims for PMS specifically. The evidence for its effectiveness is therefore anecdotal and based on patterns of historical use rather than modern scientific validation. Contemporary herbal references may still list Squaw Vine as a gentle support for menstruation and reproductive balance, but this is not supported by rigorous evidence. For PMS, the rating is low (1), reflecting the lack of scientific studies and the reliance on traditional use.
Other ingredients used for PMS (general)
ashwagandhabeet
black cohosh
borage oil
bupleurum falcatum
calcium
chamomile
chaste tree
DIM (diindolylmethane)
dong quai root
EPA (eicosapentaenoic acid)
evening primrose oil
fennel
flaxseed
gamma linolenic acid (GLA)
green tea
inositol
jujube
kudzu
licorice root
lignans
liquid liver fractions
maca
magnesium
motherwort
pollen
quail egg
relora® (proprietary)
sage
soybean
valerian root
vitamin B6
vitamin C
vitamin D
watermelon
wild yam
zinc
tangerine
bee pollen
lingusticum wallichii
royal jelly
Equol (proprietary)
peach
27-deoxyactein
Alchemilla
Aerva lanata
Agrimonia pilosa
Acetylsalicylic acid
Agnuside
Ashoka
Borage
banana
Cohosh
Calendula
Clary sage
Cnidium
Cyathula
Chocolate
Dong Quai
Eicosapentaenoic Acid
Evening Primrose
Estrogen
Lotus
Sweet Orange alcohol
Vervain
Other health conditions supported by Squaw Vine
Afterbirth PainAmenorrhea
Cramps (menstrual)
Dysmenorrhea
Endometriosis
Labor and Delivery
Menopause
Menstrual Irregularity
Menstruation (scant)
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pregnancy (herbs and supplements for)
Vaginal Dryness
Vaginitis