Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoflavones, primarily found in soy products, are phytoestrogens—plant-derived compounds with estrogen-like activity. Their use for managing premenstrual syndrome (PMS) symptoms is based on the hypothesis that these compounds may exert mild estrogenic effects, potentially modulating hormonal fluctuations that contribute to PMS. Some scientific studies have investigated the impact of isoflavones on menopausal symptoms, but evidence specific to PMS is limited and less robust.

A few small-scale clinical trials and observational studies suggest that isoflavone supplementation might offer modest relief for certain PMS symptoms such as mood swings and breast tenderness, possibly due to their ability to bind estrogen receptors and influence hormone balance. However, the quality and size of these studies are limited, and results are inconsistent. Most systematic reviews and meta-analyses conclude that while isoflavones are generally safe, there is insufficient high-quality evidence to firmly support their effectiveness for PMS.

Thus, while the use of isoflavones for PMS is grounded in plausible biological mechanisms and has been explored in preliminary research, the scientific evidence remains weak and inconclusive, meriting a low evidence rating. Further large, well-controlled studies are needed to validate any potential benefit.

More about isoflavone (unspecified)
More about PMS (general)

Other ingredients used for PMS (general)

Other health conditions supported by isoflavone (unspecified)

Products containing isoflavone (unspecified)