Evidence supporting the use of: Inositol
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Inositol, particularly as myo-inositol and D-chiro-inositol, has garnered scientific interest for its role in supporting and potentially alleviating symptoms of premenstrual syndrome (PMS). Several randomized controlled trials and observational studies have investigated inositol's effects on PMS, focusing mainly on its influence on mood-related symptoms, such as anxiety, irritability, and depression, which are common in PMS. Inositol is thought to modulate neurotransmitter signaling, particularly serotonin, which is implicated in mood regulation and is often dysregulated in PMS. Some studies, including double-blind, placebo-controlled trials, have reported improvements in mood and a reduction in the severity of PMS symptoms among women supplementing with inositol. However, the body of evidence is still relatively modest, with most studies being small in size and varying in methodology.

Inositol is better established in the treatment of polycystic ovary syndrome (PCOS), but due to overlapping symptoms—such as mood disturbances, anxiety, and metabolic changes—its use has been extrapolated to PMS. While not a first-line therapy, inositol is considered a potential adjunct for women seeking non-hormonal, well-tolerated options for PMS symptom relief. In summary, there is moderate scientific support for inositol's use in PMS, particularly for mood symptoms, but larger and more rigorous studies are needed to confirm its efficacy and establish standardized dosing protocols.

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