Evidence supporting the use of: Diindolylymethane
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and cabbage. DIM is often marketed as a supplement for hormonal balance, including support for symptoms of premenstrual syndrome (PMS). The rationale is that DIM modulates estrogen metabolism, promoting the formation of less potent estrogen metabolites, which might theoretically reduce estrogen-dominant symptoms sometimes associated with PMS.

However, the scientific evidence specifically supporting DIM for the treatment or support of PMS is limited. Most research on DIM has centered on its effects in hormone-related cancers and general estrogen metabolism. A few small human studies and animal models suggest that DIM can alter estrogen metabolite ratios, but there are no robust, well-controlled clinical trials demonstrating a clear benefit for PMS symptom relief. The majority of claims for DIM and PMS are extrapolated from its mechanism of action rather than direct clinical outcomes.

In summary, while there is a plausible biological mechanism for how DIM might influence hormone-related symptoms, direct scientific support for its use in PMS is weak, and most evidence remains preliminary. More rigorous clinical studies are needed to determine its efficacy and safety for this specific indication.

More about Diindolylymethane
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Products containing Diindolylymethane

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