Evidence supporting the use of: L-arginine
For the body system: Pituitary

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is an amino acid that serves as a precursor for nitric oxide (NO) synthesis, which plays a role in various physiological processes. It has been studied for its potential to stimulate the pituitary gland, particularly regarding growth hormone (GH) secretion. Several clinical studies have shown that oral or intravenous administration of L-arginine can acutely stimulate the release of growth hormone from the anterior pituitary, likely by suppressing somatostatin (a GH-inhibiting hormone). This effect has led to the use of L-arginine as a provocative agent in diagnostic GH stimulation tests. However, the evidence for using L-arginine as a long-term supplement to support general pituitary health or function is limited. Most research focuses on its short-term, pharmacological use under clinical supervision rather than daily supplementation for wellness or pituitary support. The effect size on GH secretion is modest and often transient, and routine supplementation does not appear to produce sustained increases in growth hormone or other pituitary hormones in healthy adults. Thus, while there is a scientific basis for L-arginine’s interaction with the pituitary, particularly for diagnostic purposes, the evidence supporting its use as a dietary supplement for overall pituitary health is weak.

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