Evidence supporting the use of: Human growth hormone
For the body system: Pituitary

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Human growth hormone (HGH), also known as somatotropin, is scientifically validated as a primary treatment for disorders associated with pituitary insufficiency. The pituitary gland produces HGH naturally, and its deficiency—often due to pituitary disease, injury, congenital defects, or tumors—leads to growth hormone deficiency (GHD) in both children and adults. Recombinant HGH therapy has been widely studied and is approved for use in individuals with confirmed GHD to restore normal growth in children and maintain healthy body composition, bone density, and metabolic function in adults.

Multiple randomized controlled trials and decades of clinical experience provide robust evidence for its efficacy in these contexts. In children, HGH therapy supports normal linear growth when endogenous production is inadequate. In adults, it improves body composition (increasing lean mass and decreasing fat mass), bone mineral density, and quality of life. The use of HGH is not justified for healthy individuals or for anti-aging purposes, as there is no substantial evidence supporting effectiveness or safety in those settings, and misuse is associated with significant risks.

Overall, the use of HGH to support the pituitary body system is strongly grounded in scientific evidence for the treatment of diagnosed deficiency, making it a cornerstone of endocrine replacement therapy in this context.

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