Evidence supporting the use of: Melatonin
For the body system: Pineal Gland
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Melatonin is a hormone naturally produced by the pineal gland, a small endocrine gland located in the brain. Its primary physiological role is the regulation of circadian rhythms, particularly the sleep-wake cycle. Scientific research has thoroughly established that melatonin production is closely linked to the functioning of the pineal gland, and exogenous melatonin supplementation is widely used to support sleep-related disorders, jet lag, and circadian rhythm disturbances. Studies show that supplemental melatonin can mimic the natural rise in endogenous melatonin secretion at night, thereby promoting sleep onset and quality (NIH: Melatonin, sleep, and circadian rhythms).
Beyond sleep regulation, melatonin also has antioxidant properties and is involved in modulating immune function, but its most validated use remains in the support and regulation of circadian rhythms—functions inherently tied to the pineal gland. The scientific consensus is strong regarding melatonin’s role in supporting physiological processes governed by the pineal gland, with extensive clinical trials and reviews confirming its efficacy (NIH: Melatonin: Nature's Most Versatile Biological Signal?). Thus, melatonin is justified by scientific evidence for supporting the body system governed by the pineal gland.
Other ingredients that support Pineal Gland
5-Hydroxytryptophan (5-HTP)gotu kola
l-tryptophan
melatonin
vitamin B6
herbal blend (proprietary)
