Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serratiopeptidase, also known as serrapeptase, is a proteolytic enzyme that has been used for its anti-inflammatory, anti-edemic, and fibrinolytic properties. The rationale for its use in phlebitis—an inflammation of the veins, often with associated clot formation—is based on its ability to reduce inflammation and promote the breakdown of inflammatory mediators and protein-based debris. Several small clinical studies and animal experiments suggest that serratiopeptidase can decrease swelling, pain, and inflammation in various conditions, including some vascular disorders. For example, some studies in the context of venous disease and trauma have shown reduced edema and improved patient comfort. However, direct, high-quality clinical trials specifically evaluating serratiopeptidase for phlebitis are limited. Most available evidence comes from broader studies on inflammation and post-surgical swelling, with phlebitis sometimes included as a secondary outcome or case report. Systematic reviews of serratiopeptidase generally acknowledge a need for higher-quality, larger-scale human trials to firmly establish its efficacy and safety for vascular inflammation such as phlebitis. Thus, while its use for phlebitis is scientifically plausible and supported by some evidence, the quality and quantity of the data remain modest, meriting a moderate-low rating on the evidence scale.

More about serratiopeptidase
More about Phlebitis

Other ingredients used for Phlebitis

Other health conditions supported by serratiopeptidase

Products containing serratiopeptidase

Nature's Sunshine AIVIA Performance Probiotic