Evidence supporting the use of: Rutin
For the health condition: Phlebitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rutin is a flavonoid glycoside commonly found in various plants, including buckwheat, citrus fruits, and apples. Its use in the management of phlebitis (inflammation of veins) is supported by some scientific evidence, though the quality and quantity of clinical data remain limited. Rutin is known to strengthen blood vessels, reduce capillary fragility, and exhibit anti-inflammatory and antioxidant properties. Several animal and small-scale human studies have shown that rutin, often in combination with other bioflavonoids like diosmin and hesperidin, can reduce symptoms of chronic venous insufficiency, such as swelling, pain, and heaviness in the legs, which are also seen in phlebitis. The mechanism of action is thought to involve inhibition of vascular permeability and reduction of inflammatory mediators. In Europe, formulations containing rutin have been used for decades to manage venous diseases, with some positive clinical outcomes reported. However, large, well-controlled trials specifically evaluating rutin for acute phlebitis are lacking. Most evidence is extrapolated from its effects on broader chronic venous disorders. In summary, while some scientific studies suggest that rutin may be beneficial for venous inflammation and support its use in conditions like phlebitis, the evidence is not robust. Its use is justified by a combination of mechanistic rationale, modest clinical data, and historical precedent in European phytotherapy. Further research is needed to establish its effectiveness specifically for phlebitis.

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