Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin methylchalcone is primarily used in the management of chronic venous insufficiency (CVI), which often includes symptoms such as phlebitis (inflammation of the veins). Several clinical studies and reviews suggest that hesperidin methylchalcone, often in combination with other flavonoids like diosmin, can help reduce inflammation, improve venous tone, decrease capillary permeability, and alleviate symptoms such as pain and edema in patients with venous disorders. The mechanism of action is thought to be related to its antioxidant properties and ability to strengthen vascular walls, thereby reducing inflammatory processes in the veins.

For example, a number of randomized controlled trials and meta-analyses have reported beneficial effects of micronized purified flavonoid fractions (which include hesperidin methylchalcone) in improving symptoms of CVI and reducing the risk or severity of phlebitis, particularly in patients with superficial venous disorders. However, while the evidence is generally supportive, it is not as robust or specific to phlebitis alone, and most studies focus on broader venous insufficiency or varicose vein symptoms. The ingredient is included in several European guidelines as a supportive treatment for venous disorders.

In summary, the use of hesperidin methylchalcone for phlebitis is supported by moderate quality scientific evidence, especially as part of a comprehensive approach to chronic venous disorders, though it is not a standalone or primary therapy for acute phlebitis.

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