Prebiotic blends—typically comprising fibers such as inulin, fructooligosaccharides (FOS), galactooligosaccharides (GOS), and other nondigestible carbohydrates—are used to support gut-associated lymphoid tissue (GALT) function, which includes Peyer’s patches. Peyer’s patches are specialized lymphoid follicles in the small intestine that play a crucial role in immune surveillance and initiation of immune responses to gut antigens.

Scientific studies in both animal and human models demonstrate that prebiotics can modulate gut microbiota composition, leading to increased production of short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate. These SCFAs and changes in microbial populations have been shown to interact with GALT, including Peyer’s patches, influencing immune cell activity, antibody production (especially IgA), and overall mucosal immunity. For example, research indicates that prebiotic supplementation can enhance the number and function of immune cells in Peyer’s patches and increase secretory IgA levels, which is a key immune defense in the gut (Roberfroid, 2012).

However, while the mechanistic connection is established and animal data are relatively strong, human evidence, though promising, is less direct and sometimes inconsistent. As a result, the prebiotic blend's support for Peyer’s patches is scientifically plausible and supported by moderate evidence but not conclusively proven in large-scale human trials.