Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei is a probiotic bacterium that has been studied for its effects on the gut-associated lymphoid tissue (GALT), of which Peyer’s patches are a critical component. Peyer’s patches are clusters of lymphoid follicles in the small intestine that play an essential role in immune surveillance and modulation. Several preclinical studies, mainly in animal models, suggest that certain strains of L. paracasei may influence the activity of immune cells within Peyer’s patches, enhancing mucosal immune responses, modulating cytokine production, and increasing secretory IgA (sIgA) production. For instance, some animal studies have demonstrated increased IgA-secreting cells in Peyer’s patches following oral administration of L. paracasei. A few small human studies and in vitro experiments indicate similar immunomodulatory properties, but evidence in humans is limited and often strain-specific.

Overall, while there is a scientific rationale for the use of L. paracasei to support the immune functions associated with Peyer’s patches, the direct clinical evidence in humans is not robust, and much of the current understanding is extrapolated from basic and preclinical research. Therefore, the evidence level is rated as 2/5, reflecting preliminary but promising findings that require further clinical validation.

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