Evidence supporting the use of: Colostrum
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Colostrum, the first form of milk produced by mammals immediately following delivery, is rich in immunoglobulins, growth factors, cytokines, and other bioactive molecules. Its use to support the immune system, and specifically the gut-associated lymphoid tissue (GALT) such as Peyer’s patches, has been the subject of scientific investigation. Peyer’s patches are important lymphoid structures in the small intestine that play a crucial role in the development and function of mucosal immunity.

Several studies indicate that oral supplementation with bovine colostrum can enhance various aspects of the gut immune response. Research in animal models and some human studies has shown that colostrum can increase the number and activity of immune cells in the gut, promote the maturation of Peyer’s patches, and stimulate the production of secretory IgA (sIgA), a key antibody involved in mucosal defense. These effects are attributed to the high concentration of immunoglobulins and growth factors contained in colostrum, which can interact with intestinal immune cells directly or indirectly via modulation of the gut microbiota.

While more large-scale human clinical trials are needed, current evidence supports the idea that colostrum supplementation can positively influence the immune function of Peyer’s patches and the wider GALT system. Reviews and experimental studies published in journals such as Clinical and Experimental Immunology and Nutrition Research Reviews provide a scientific rationale for its use in supporting gut immune health, earning it a rating of 4 out of 5 for evidence.

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