Evidence supporting the use of: Bifidobacterium bifidum
For the body system: Peyer’s patches

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium bifidum is a probiotic bacterium commonly found in the human gastrointestinal tract. There is some scientific evidence suggesting that B. bifidum, along with other bifidobacteria, may influence immune function in the gut, including effects on Peyer’s patches—aggregated lymphoid nodules in the small intestine critical for immune surveillance and response. Studies, primarily in animal models and in vitro, demonstrate that certain Bifidobacterium strains can enhance IgA production and modulate immune cell activity within Peyer’s patches. For example, research has shown that administration of B. bifidum can increase the number of IgA-producing cells and stimulate secretory immunoglobulin A (sIgA) levels, suggesting a role in mucosal immunity.

However, direct human clinical data specifically linking B. bifidum supplementation to functional improvement in Peyer’s patches are limited. Most human studies address broader immune parameters or general gut health rather than focused outcomes related to Peyer’s patch activity. Therefore, while there is some scientific rationale and preclinical evidence for B. bifidum supporting immune function associated with Peyer’s patches, the strength of evidence remains modest and not definitive. Further targeted clinical research is needed to confirm these effects in humans.

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