Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Beta-glucans are naturally occurring polysaccharides found in the cell walls of cereals, bacteria, and fungi. Their immunomodulatory effects have been scientifically investigated, particularly in relation to the gut-associated lymphoid tissue (GALT), of which Peyer’s patches are a crucial component. Peyer’s patches are clusters of lymphoid follicles in the small intestine that play a key role in immune surveillance and the initiation of immune responses to antigens present in the gut.

Several animal and in vitro studies have shown that orally administered beta-glucans can interact with immune cells in Peyer’s patches, stimulating dendritic cells and macrophages, and enhancing the production of secretory IgA (sIgA). For example, research published in International Immunopharmacology (2007) and Journal of Nutrition (2009) demonstrated that beta-glucans can be taken up by M cells overlying Peyer’s patches, leading to immune activation. There is also evidence suggesting that regular consumption of beta-glucans may improve host defense against pathogens by boosting mucosal immunity.

However, most evidence is preclinical, and direct human data on beta-glucans specifically enhancing Peyer’s patch function are limited. While beta-glucans are widely recognized for their general immunomodulatory benefits, more robust clinical trials are needed to fully substantiate their role in supporting Peyer’s patches specifically. Accordingly, the current level of scientific evidence is moderate.

More about Beta-Glucan
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Other ingredients that support Peyer’s patches

Other body systems supported by Beta-Glucan

Products containing Beta-Glucan

Nature's Sunshine Immune System
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Nature's Sunshine Proactazyme®