Bacteria, particularly probiotic strains, are scientifically validated to support the function and health of Peyer’s patches, which are specialized lymphoid follicles in the small intestine that play a critical role in the gut-associated lymphoid tissue (GALT) and overall immune system. Peyer’s patches sample antigens from the gut lumen and help generate immune responses, including the production of IgA antibodies. Numerous studies have demonstrated that specific probiotic bacteria such as Lactobacillus and Bifidobacterium can interact with Peyer’s patches and enhance their immunological activity.

Research shows that these bacteria can stimulate dendritic cells and other immune cells within the Peyer’s patches, leading to improved mucosal immunity and a balanced immune response. Animal and human studies provide evidence that oral administration of probiotics increases the number and activity of immune cells in Peyer’s patches, enhances the secretion of protective IgA, and may contribute to defense against gut pathogens.

While most research focuses on probiotics’ general immune and gut health benefits, the mechanistic relationship with Peyer’s patches has been specifically observed in experimental models. However, not all probiotic strains exert the same effect, and more research is needed to specify which strains and doses provide optimal support. Overall, the use of bacteria to support the Peyer’s patches is well-founded in scientific literature, meriting a strong evidence rating.