Evidence supporting the use of: Shiitake mushroom
For the health condition: Pets (supplements for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Shiitake mushrooms (Lentinula edodes) have been used in traditional Asian medicine for centuries, but their inclusion in pet supplements is increasingly supported by emerging scientific evidence. Shiitake mushrooms are rich in bioactive compounds, notably beta-glucans, polysaccharides, and lentinan, which have demonstrated immunomodulatory, antiviral, and anti-inflammatory properties in laboratory and animal studies. In pets, especially dogs and cats, these compounds are believed to help support immune system function, promote overall wellness, and potentially aid in the management of certain chronic conditions or infections.

Several studies in dogs have shown that supplementation with shiitake mushroom extracts can enhance immune markers and may improve resistance to infections. For example, pilot studies have demonstrated improved lymphocyte (white blood cell) function and reduced markers of inflammation. However, the majority of these studies are small-scale, and there is a lack of large, well-controlled clinical trials directly correlating shiitake supplementation with significant clinical outcomes in pets. As such, while the theoretical and preliminary scientific basis is promising, the strength of evidence remains moderate (rated 2 out of 5). Pet owners should consult veterinarians before starting any mushroom-based supplement, especially in animals with underlying health conditions or those on immunosuppressive therapy.

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