Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B12 is scientifically validated as an essential treatment for pernicious anemia. Pernicious anemia is a type of megaloblastic anemia caused by impaired absorption of vitamin B12 due to a lack of intrinsic factor, a protein produced in the stomach. Without intrinsic factor, vitamin B12 from dietary sources cannot be absorbed effectively, leading to deficiency. Vitamin B12 is vital for DNA synthesis, especially in red blood cell production; its deficiency results in the production of large, immature, and dysfunctional red blood cells, characteristic of megaloblastic anemia.

The use of vitamin B12 in treating pernicious anemia was established in the early 20th century, when researchers discovered that patients improved after consuming liver (a rich source of B12). Later, it was determined that the therapeutic effect was due to vitamin B12, leading to the development of injectable and oral vitamin B12 supplements. Numerous clinical studies and decades of clinical practice have shown that vitamin B12 supplementation (primarily by intramuscular injection, but also high-dose oral routes) reverses the hematological and neurological symptoms of the disease.

As a result, vitamin B12 is the standard, evidence-based treatment for pernicious anemia, and its use is supported by leading medical guidelines and extensive clinical evidence.

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