Evidence supporting the use of: Vitamin B12 (Hydroxycobalamin)
For the health condition: Pernicious Anemia

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B12 (Hydroxycobalamin) is scientifically validated as a treatment for pernicious anemia. Pernicious anemia is an autoimmune condition that impairs the absorption of vitamin B12 in the gastrointestinal tract due to the destruction of intrinsic factor, a protein required for B12 absorption in the ileum. Without sufficient B12, the body cannot produce healthy red blood cells, leading to megaloblastic anemia and neurological complications.

Hydroxycobalamin, a form of vitamin B12, is used therapeutically because it can be administered intramuscularly or intravenously, bypassing the need for intrinsic factor and the gastrointestinal tract. Numerous clinical studies and decades of medical use have demonstrated that parenteral (non-oral) vitamin B12 administration corrects the anemia, reverses neurological symptoms if caught early, and restores normal hematologic parameters. Major medical guidelines, including those from the World Health Organization and hematology associations, recommend hydroxycobalamin or cyanocobalamin injections as the standard of care for pernicious anemia.

Hydroxycobalamin is preferred in some regions (such as the UK) for its longer duration of action compared to cyanocobalamin, requiring less frequent injections. The scientific basis for its use is robust, supported by randomized controlled trials, long-term observational data, and pathophysiological understanding of the disease mechanism. Thus, its use in treating pernicious anemia is fully justified on scientific grounds.

More about Vitamin B12 (Hydroxycobalamin)
More about Pernicious Anemia

Products containing Vitamin B12 (Hydroxycobalamin)

We currently have no products on Caring Sunshine that contain this ingredient.