Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Methylcobalamin is a form of vitamin B12, an essential nutrient required for DNA synthesis, red blood cell formation, and neurological function. Pernicious anemia is a condition most commonly caused by autoimmune destruction of gastric parietal cells, resulting in impaired production of intrinsic factor and, consequently, poor absorption of vitamin B12 from the gastrointestinal tract. The hallmark of pernicious anemia is vitamin B12 deficiency, leading to megaloblastic anemia and potentially severe neurological complications if left untreated.

There is strong scientific evidence supporting the use of vitamin B12 to treat pernicious anemia. Traditionally, cyanocobalamin and hydroxocobalamin have been used as parenteral (injection) therapies because oral absorption is compromised in these patients. Methylcobalamin is another active and bioavailable form of vitamin B12, and numerous studies demonstrate that it is effective at correcting both hematologic and neurological abnormalities associated with B12 deficiency, including in patients with pernicious anemia.

Clinical guidelines and research recognize methylcobalamin as equivalent to other vitamin B12 forms in efficacy, provided it is administered parenterally (or in high oral doses that bypass intrinsic factor-dependent absorption). The scientific consensus is that the therapeutic benefit is due to the correction of B12 deficiency, regardless of the specific B12 form. Therefore, the use of methylcobalamin for pernicious anemia is fully scientifically justified and evidence-based.

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