Evidence supporting the use of: Vitamin B12 (cyanocobalamin)
For the health condition: Peripheral Neuropathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12 (cyanocobalamin) is scientifically validated for use in the management and treatment of peripheral neuropathy, especially when the neuropathy is caused by B12 deficiency. Peripheral neuropathy involves damage to the peripheral nerves, leading to symptoms such as tingling, numbness, and weakness, most commonly in the hands and feet. B12 is essential for normal nerve function and myelin sheath synthesis. Deficiency of this vitamin can cause demyelination and axonal degeneration, which are classic features of neuropathy.

Multiple clinical studies and case reports have established that B12 supplementation—by oral or intramuscular routes—can reverse or halt progression of neuropathy in patients with documented B12 deficiency. For example, a 2017 review in Current Neurology and Neuroscience Reports confirms that B12 supplementation is an accepted standard of care in deficiency-mediated neuropathy, improving both neurological and hematological symptoms. However, for neuropathies not related to B12 deficiency, the benefit of B12 supplementation is less clear; most evidence supports its use specifically in deficiency states.

Thus, B12 is not a universal treatment for all forms of peripheral neuropathy, but its use is strongly evidence-based in those with laboratory-confirmed deficiency, such as those with pernicious anemia, malabsorption syndromes, or certain dietary patterns (e.g., strict veganism). The evidence rating is high (4/5), reflecting robust support for this specific indication.

More about Vitamin B12 (cyanocobalamin)
More about Peripheral Neuropathy

Other health conditions supported by Vitamin B12 (cyanocobalamin)

Anemia
Depression
Fatigue
Memory and Brain Function
Peripheral Neuropathy
Pernicious Anemia
Wasting

Products containing Vitamin B12 (cyanocobalamin)

We currently have no products on Caring Sunshine that contain this ingredient.