Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hericium mushroom, also known as Lion's Mane (Hericium erinaceus), has attracted scientific interest for its potential neuroprotective properties, particularly in relation to peripheral neuropathy. Preclinical studies—primarily in vitro and animal models—have demonstrated that extracts of Hericium erinaceus can promote the synthesis of nerve growth factor (NGF), which plays a key role in the growth, maintenance, and survival of neurons. Several rodent studies have reported improvements in nerve regeneration and functional recovery following nerve injury when treated with Hericium extracts. For example, a study published in "International Journal of Medicinal Mushrooms" (2013) found that oral administration of Hericium promoted recovery from peripheral nerve injury in rats. Another study in "Journal of Ethnopharmacology" (2014) showed protective effects against diabetic neuropathy in mice. However, clinical trials in humans are very limited. A small number of human studies have focused on cognitive function or mild cognitive impairment, rather than peripheral neuropathy specifically. There is insufficient high-quality clinical evidence directly supporting its use for peripheral neuropathy in humans, although the biological plausibility and promising preclinical findings have prompted ongoing interest. Thus, while the use of Hericium for peripheral neuropathy is grounded in early scientific research, robust clinical validation is lacking, and more studies are needed to confirm efficacy and safety in humans.

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