Ginkgo biloba is sometimes used to support or treat peripheral neuropathy, primarily based on scientific interest and limited clinical evidence. Ginkgo biloba extract contains flavonoids and terpenoids that are believed to have neuroprotective and vasodilatory effects, which could theoretically benefit patients with peripheral neuropathy by improving blood flow and reducing oxidative damage to nerves.

A few small-scale clinical studies suggest that Ginkgo biloba may provide symptom relief for patients with peripheral neuropathy, especially when the condition is related to diabetes. For example, preliminary research has indicated improvements in nerve conduction and reductions in neuropathic pain in some study groups. Animal studies also support potential benefits, with findings such as reduced nerve damage and improved nerve function following Ginkgo administration. However, most of these studies are either limited in size, not well-controlled, or show only modest effect sizes.

Major medical guidelines do not currently endorse Ginkgo biloba as a primary treatment for peripheral neuropathy, emphasizing the need for larger, high-quality randomized controlled trials. Overall, while there is some scientific rationale and early evidence for its use, the strength of the evidence is limited (rated 2 out of 5), and it should not replace established treatments. Patients interested in Ginkgo biloba should consult healthcare providers before use due to possible interactions and side effects.