Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgo biloba is sometimes used as a complementary approach to support peripheral neuropathy, particularly due to its purported neuroprotective and microcirculatory effects. The scientific evidence, however, is limited and mixed. Some animal studies and small clinical trials suggest Ginkgo extract may help improve nerve function and alleviate symptoms such as numbness and tingling, possibly through antioxidant properties, inhibition of platelet-activating factor, and enhancement of blood flow. For example, a few randomized controlled trials (RCTs) have investigated Ginkgo in diabetic neuropathy and chemotherapy-induced neuropathy, showing modest improvements in symptoms compared to placebo, but these studies often have small sample sizes and methodological limitations. Systematic reviews and meta-analyses generally conclude that the quality of evidence is low and results are inconsistent, with insufficient data to recommend Ginkgo as a primary therapy.

Traditionally, Ginkgo has been used in Chinese medicine for circulatory disorders, but its specific use for peripheral neuropathy is not well documented in historical texts. Overall, while there is a scientific rationale for investigating Ginkgo in peripheral neuropathy, current clinical evidence is weak and does not robustly support its widespread use for this condition. Ginkgo may be considered as an adjunct, but not a replacement for established therapies, and should be used with caution due to potential drug interactions and side effects.

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