Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Anthocyanosides, a group of flavonoid compounds found in berries like bilberry and blueberry, have a long history of traditional use for various vascular and eye-related conditions. Their use in treating or supporting peripheral neuropathy stems primarily from their purported ability to strengthen blood vessels, improve microcirculation, and exert antioxidant effects, rather than from direct evidence in neuropathic conditions. In traditional European herbal medicine, bilberry extracts rich in anthocyanosides have been recommended to support capillary health and circulation, which, by extension, is sometimes thought to aid in conditions involving nerve health or peripheral blood flow.

However, scientific evidence specifically supporting anthocyanosides for peripheral neuropathy is limited. Most research focuses on their vascular benefits or their role in diabetic retinopathy, not direct nerve protection or symptom improvement in neuropathy. Some preclinical studies suggest antioxidants like anthocyanosides could theoretically reduce oxidative stress implicated in nerve damage, but human clinical trials for neuropathy are lacking. Overall, the rationale for their use in peripheral neuropathy is based more on an extrapolation from traditional vascular uses and general antioxidant properties rather than robust scientific validation for this particular indication.

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