Evidence supporting the use of: Vitamin D3
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) is being investigated for its potential role in supporting individuals with Parkinson’s Disease (PD), but the evidence is still emerging and not definitive. Observational studies have shown that people with PD often have lower serum vitamin D levels compared to healthy controls. Since vitamin D receptors are present in many brain regions, including those affected by PD, and vitamin D is involved in neuroprotection, immune modulation, and regulation of inflammation, researchers have hypothesized that it might influence PD progression or symptom severity.

Several small clinical studies and meta-analyses suggest that vitamin D supplementation may help slow the progression of motor symptoms and reduce the risk of falls in PD patients, likely due to its effects on muscle strength and balance. For example, a 2013 randomized controlled trial found that vitamin D supplementation helped maintain balance in PD patients. However, other studies have not found significant benefits, and no large-scale, definitive trials have shown that vitamin D3 supplementation can prevent, treat, or significantly modify the course of PD.

Overall, while there is a scientific rationale and some observational and interventional evidence suggesting a possible supportive role for vitamin D3 in PD, the current level of evidence is limited (rated 2/5). Supplementation may be justified to correct deficiency and promote general health, but it should not be considered a primary treatment for Parkinson’s Disease until more robust data are available.

More about vitamin D3
More about Parkinson's Disease