Evidence supporting the use of: Spirulina
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Spirulina, a blue-green algae, has garnered scientific interest for its potential neuroprotective effects, including possible benefits in Parkinson's Disease (PD). Preclinical studies in animal models have shown that spirulina possesses antioxidant and anti-inflammatory properties, which are relevant because oxidative stress and neuroinflammation contribute to the degeneration of dopaminergic neurons in PD. Several rodent studies have demonstrated that supplementation with spirulina may reduce neuronal loss and improve motor function in toxin-induced models of Parkinson’s Disease. For example, research published in journals such as Neurobiology of Disease has shown that diets enriched with spirulina can attenuate neurodegeneration and modulate microglial activation in animal models.

Despite these promising findings, there is a lack of robust clinical evidence in humans. No large-scale, well-controlled clinical trials have been conducted to confirm efficacy or safety of spirulina for patients with PD. The bulk of the current evidence is limited to laboratory and animal studies, which do not always translate to human benefits. As such, while the scientific rationale for using spirulina in Parkinson’s Disease is grounded in mechanistic and preclinical data, the overall evidence supporting its use in humans is weak (rated 2/5). Patients should consult healthcare providers before using spirulina as a complementary therapy.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone