Evidence supporting the use of: Myricetin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Myricetin is a natural flavonoid found in many fruits, vegetables, and plants. Its potential use for Parkinson’s Disease (PD) is supported by preclinical scientific evidence, primarily from in vitro (cell culture) and animal studies. Research indicates that myricetin possesses strong antioxidant and anti-inflammatory properties, both of which are relevant to the pathogenesis of PD, a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Several studies have demonstrated that myricetin can protect neuronal cells from oxidative stress-induced apoptosis and may inhibit neuroinflammation by modulating signaling pathways such as NF-κB.

Animal model studies have shown that myricetin administration can attenuate motor deficits and neuronal loss in models of PD induced by toxins like MPTP or 6-OHDA. The protective effects are believed to result from its ability to scavenge reactive oxygen species, reduce lipid peroxidation, and modulate apoptotic pathways. However, there are currently no robust clinical trials in humans to validate these findings, and myricetin is not an approved or standard treatment for Parkinson’s Disease. Thus, while there is preliminary scientific rationale, the evidence is limited to preclinical studies, and more research is needed to establish safety and efficacy in humans.

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Products containing Myricetin

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