Evidence supporting the use of: Mangiferin
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangiferin, a polyphenolic compound found primarily in mangoes (Mangifera indica), has garnered interest for its neuroprotective and antioxidant properties. Preclinical studies have investigated its potential benefits for neurodegenerative diseases, including Parkinson’s Disease (PD). Several animal studies suggest that mangiferin may exert neuroprotective effects through multiple mechanisms, such as reduction of oxidative stress, inhibition of neuroinflammation, and mitigation of dopaminergic neuronal loss. For instance, rodent models of PD induced by neurotoxins like MPTP or rotenone have shown that mangiferin administration can reduce behavioral deficits and protect dopaminergic neurons, likely by attenuating oxidative damage and modulating inflammatory pathways (e.g., Nrf2/ARE signaling).

However, as of June 2024, there is no robust clinical evidence in humans to support the use of mangiferin as a treatment or adjunct therapy for Parkinson’s Disease. The evidence remains limited to in vitro and animal studies, which, while promising, are insufficient to justify clinical use. No major traditional medicine systems are documented as using mangiferin or mango extracts specifically for Parkinson’s Disease. In summary, the scientific rationale is based on preclinical findings with a low (2/5) evidence rating, and further research, especially human clinical trials, is needed before mangiferin can be recommended for PD management.

More about mangiferin
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing mangiferin

We currently have no products on Caring Sunshine that contain this ingredient.