Evidence supporting the use of: Ferulic acid derivative
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ferulic acid derivatives have garnered scientific interest for their potential neuroprotective effects in Parkinson’s Disease (PD), primarily based on preclinical studies. Ferulic acid is a plant-derived phenolic compound with antioxidant, anti-inflammatory, and anti-apoptotic properties. In animal and cell models of PD, ferulic acid and its derivatives have been shown to attenuate dopaminergic neuronal loss, reduce oxidative stress, inhibit neuroinflammation, and modulate mitochondrial dysfunction—mechanisms that are relevant to PD pathogenesis. For instance, studies published in peer-reviewed journals such as Neurochemistry International and Neurotoxicity Research have demonstrated that ferulic acid treatment protected against neurotoxicity induced by MPTP and 6-OHDA, two toxins commonly used to model PD in rodents.

Despite these promising preclinical findings, clinical evidence in humans is lacking. No substantial randomized controlled trials or large cohort studies have been conducted to establish efficacy or safety of ferulic acid derivatives in PD patients. Thus, while there is a scientific rationale and early experimental support for their use, the current evidence is limited to laboratory research and does not yet justify clinical application. Further studies, particularly in humans, are required to validate these benefits and determine appropriate dosing and safety profiles.

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