Evidence supporting the use of: Eicosapentaenoic acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic Acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in fish oil, and its use in Parkinson’s Disease (PD) is supported by limited scientific evidence. The rationale for EPA supplementation in PD is based on its potential neuroprotective, anti-inflammatory, and membrane-stabilizing effects. Some small-scale clinical studies and preclinical research suggest that omega-3 fatty acids, including EPA, can reduce neuroinflammation and oxidative stress, both implicated in PD pathogenesis. For example, a randomized controlled trial (da Silva et al., 2008) found that omega-3 supplementation, combined with antioxidant vitamins, led to improvements in depression symptoms in PD patients. However, its direct effect on the motor symptoms or progression of PD remains unclear, and larger, high-quality trials are lacking.

EPA is not a standard or primary therapy for PD, and medical guidelines do not currently recommend its use for disease modification or symptomatic management. The evidence base is limited to small studies with mixed outcomes, and most research has focused on the general neuroprotective effects of omega-3s rather than EPA specifically. As such, while there is scientific interest and some preliminary data, the strength of evidence is weak and does not support routine use of EPA as a treatment for Parkinson’s Disease at this time.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing eicosapentaenoic acid

We currently have no products on Caring Sunshine that contain this ingredient.