Evidence supporting the use of: 7,8-Dihydroxyflavone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7,8-Dihydroxyflavone (7,8-DHF) is a small-molecule compound that acts as a selective agonist of the TrkB receptor, mimicking brain-derived neurotrophic factor (BDNF) activity. BDNF-TrkB signaling is known to play a crucial role in neuronal survival, plasticity, and repair, processes that are disrupted in neurodegenerative diseases such as Parkinson’s Disease (PD). Preclinical studies have investigated the neuroprotective effects of 7,8-DHF in various models of PD. For example, administration of 7,8-DHF in rodent models has been shown to protect dopaminergic neurons from toxin-induced degeneration, improve motor function, and reduce oxidative stress and inflammation in the substantia nigra. These findings suggest a potential disease-modifying effect in PD, at least in animal models.

However, there is currently no robust clinical evidence supporting the use of 7,8-DHF in humans with Parkinson’s Disease. The evidence base consists almost entirely of laboratory and animal studies (e.g., Chen et al., 2015, Neurobiology of Disease; Jang et al., 2010, PNAS), with a lack of published human trials. Therefore, while the scientific rationale and preclinical results are promising, the overall strength of evidence is rated as moderate to low (2/5) due to the absence of human data. More clinical research is needed to determine safety, efficacy, and appropriate dosing in humans before 7,8-DHF can be recommended for PD.

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