Evidence supporting the use of: Valerian root
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Valerian root (Valeriana officinalis) has a long history of use as a traditional herbal remedy for promoting relaxation and sleep. Modern research suggests that valerian root may support the parasympathetic nervous system, which governs the body's "rest and digest" responses. The proposed mechanism involves valerian's ability to modulate gamma-aminobutyric acid (GABA) activity in the brain. GABA is the primary inhibitory neurotransmitter, and its enhanced action can promote calming effects, which are associated with parasympathetic activation.

Several clinical studies have shown that valerian root extract can reduce subjective symptoms of anxiety and improve sleep quality, though results are mixed and often limited by study design, sample size, and variability in valerian preparations. For example, a 2020 meta-analysis in Sleep Medicine found that valerian had a modest but statistically significant effect on improving sleep quality compared to placebo. Preclinical studies also demonstrate that valerian extracts can increase GABAergic activity, which may help tilt the autonomic nervous system balance toward parasympathetic dominance.

Overall, while the evidence is not overwhelmingly strong or conclusive, there is moderate scientific support for valerian root's ability to promote relaxation and support the parasympathetic nervous system, primarily through its effects on GABA signaling. Further large-scale, high-quality clinical trials are needed to better establish its efficacy and clarify its mechanisms of action.

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Other body systems supported by valerian root

Brain
GABA
Nerves
Parasympathetic Nervous System