Evidence supporting the use of: Magnolia
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnolia bark (Magnolia officinalis) has been traditionally used in Chinese medicine for its calming and anti-anxiety properties. Recent scientific studies have begun to elucidate its effects on the nervous system, particularly in relation to the parasympathetic nervous system. The primary active compounds in magnolia, honokiol and magnolol, have demonstrated anxiolytic (anxiety-reducing) and sedative effects in animal models, primarily by modulating GABAergic neurotransmission, which is closely linked to parasympathetic activity. Some studies have shown that magnolia extracts can reduce stress-induced physiological responses and promote relaxation, suggesting a shift toward parasympathetic dominance (the "rest and digest" state). Human clinical trials are limited but suggest potential benefits for stress reduction and improved sleep quality. However, more robust, large-scale human studies are needed to confirm these effects and clarify the mechanisms. Overall, there is a growing body of preclinical and some clinical evidence supporting the use of magnolia to support parasympathetic nervous system function, but the strength of the evidence is moderate at this time.

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