Evidence supporting the use of: Senna occidentalis
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Senna occidentalis (also known as Coffee Senna) has a long history of use in traditional medicine, particularly in Africa, Asia, and South America, for the treatment of intestinal parasites such as nematodes and worms. Traditional healers often use decoctions or infusions of the leaves, seeds, or roots as an anthelmintic—agents that expel parasitic worms from the body. Ethnobotanical surveys and historical texts document this application, citing its inclusion in remedies for both humans and livestock afflicted with worm infestations.

Despite this widespread traditional use, scientific support for the efficacy and safety of Senna occidentalis against parasitic worms is limited. A few in vitro and animal studies have suggested mild to moderate anthelmintic activity, but the results are inconsistent and often not directly translatable to clinical practice. Moreover, some reports raise concerns about the plant's toxicity—particularly to the liver and muscles—when used in large quantities or over long durations. The primary compounds believed to contribute to its anthelmintic properties are anthraquinones, although these are more commonly associated with the well-known laxative effects of related Senna species. Overall, while there is a clear tradition of use for parasites, robust clinical trials and safety evaluations are lacking.

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