Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Kamala (Mallotus philippensis), also known as Kamala powder or red kamala, has a long history of use in traditional medicine systems, particularly in Ayurveda and Unani, as an anthelmintic agent for the treatment of intestinal parasites (such as nematodes and tapeworms). Its reddish powder, derived from the fruit glands and hairs, has been employed for centuries in South Asian folk medicine to expel worms and treat related gastrointestinal complaints.

The anthelmintic activity of Kamala is attributed to its content of bioactive compounds, such as rottlerin and related phloroglucinol derivatives, which are believed to disrupt the metabolic processes of worms. While there are a few animal studies and in vitro investigations suggesting effectiveness against certain helminths, high-quality clinical trials in humans are lacking. Most of the available evidence is anecdotal or derived from traditional texts and historical records.

Therefore, Kamala’s use for treating intestinal parasites is primarily justified by traditional use, with limited low-level scientific investigation but not enough to elevate the evidence rating. Safety concerns, including reports of gastrointestinal irritation and toxicity at higher doses, also limit its modern medical application. In summary, the use of Kamala for nematodes and worms is rooted in tradition, supported by some historical and low-level preclinical evidence, but lacks robust scientific validation.

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