Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alchornea cordifolia is used in traditional African medicine to treat various parasitic infections, particularly intestinal worms (helminths) and nematodes. Scientific research supports this traditional use to a moderate extent. Several in vitro and in vivo studies have demonstrated that extracts from A. cordifolia leaves, stem bark, and roots possess anthelmintic activity. For example, studies published in peer-reviewed journals have shown that aqueous and ethanol extracts of the plant can cause significant mortality and reduced motility in nematodes such as Haemonchus contortus and Pheretima posthuma. These findings indicate that compounds in A. cordifolia, including alkaloids, flavonoids, and saponins, may exert direct toxic effects on parasitic worms.

However, while laboratory and animal studies provide promising results, robust clinical trials in humans are lacking. The evidence base remains limited to preclinical research and ethnobotanical records. The mechanism of action is not fully elucidated, but likely involves disruption of the parasite’s cell membranes and metabolic pathways. In summary, the use of Alchornea cordifolia for treating parasitic infections is supported by both traditional use and preliminary scientific evidence, but more rigorous clinical studies are needed to justify its widespread therapeutic application.

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