Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Alchornea cordifolia has a longstanding history of traditional use in African ethnomedicine for the treatment of various parasitic infections, including intestinal worms and protozoan infestations. Ethnobotanical surveys document its use across several West and Central African communities, where leaf and root extracts are administered as decoctions or infusions against parasites such as Plasmodium (malaria), Entamoeba histolytica, and helminths. The plant contains bioactive compounds, such as alkaloids, flavonoids, and tannins, which are hypothesized to contribute to its antiparasitic effects.

While a limited number of in vitro and animal studies have demonstrated activity against certain parasites (e.g., antiplasmodial and antihelminthic effects), clinical evidence in humans remains insufficient. The majority of available evidence is thus rooted in traditional knowledge and preliminary laboratory research, rather than robust clinical trials. Despite this, the consistency of its use in traditional medicine and some positive laboratory findings support a moderate level of evidence (3/5) for its traditional antiparasitic application. Further clinical research is needed to validate efficacy and safety in human populations.

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