Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ajoene, a sulfur-containing compound derived from garlic (Allium sativum), has a longstanding history in traditional medicine for its antimicrobial and antiparasitic properties. Garlic, and by extension ajoene, has been used across various cultures for centuries to address parasitic infections, including intestinal worms and protozoa. The traditional use is primarily based on garlic's broad-spectrum antimicrobial effects, rather than on specific, well-controlled clinical trials of ajoene itself. Some in vitro and animal studies suggest ajoene may have activity against certain parasites, such as Trypanosoma cruzi and Leishmania species, by disrupting cellular membranes and interfering with parasite metabolism. However, these studies are limited in scope, and robust human clinical trials are lacking. The traditional use remains the main justification for ajoene in supporting antiparasitic therapies, with scientific validation still preliminary. Therefore, while there is a foundation of traditional use and some promising preclinical data, there is insufficient high-quality clinical evidence to strongly support ajoene’s effectiveness against general parasitic infections in humans.

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