Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Citrus maxima, commonly known as pomelo, has a history of use in traditional medicine systems, particularly in Southeast Asia and parts of South Asia. Traditional healers have used various parts of the plant—especially the fruit peel and leaves—as remedies for general pain, including headaches, muscle pain, and as poultices for rheumatic conditions. These practices are documented in folk medicine literature and ethnobotanical surveys, which report the external application of Citrus maxima extracts or decoctions to alleviate discomfort.

While these uses are well established in traditional practice, scientific validation is limited. A few preclinical studies have investigated the analgesic and anti-inflammatory properties of pomelo extracts. For example, some animal model studies suggest that methanolic or aqueous extracts of Citrus maxima leaves and peels may reduce pain-related behaviors, likely due to the presence of flavonoids, limonoids, and essential oils with known anti-inflammatory effects. However, these studies are preliminary, not always peer-reviewed, and there is a lack of human clinical trials. As a result, the evidence supporting the efficacy and safety of Citrus maxima for pain relief remains modest and primarily anecdotal.

In summary, the use of Citrus maxima for general pain relief is mainly justified by traditional use, with limited scientific support from animal studies and no robust clinical trials in humans.

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