Chinese Fleeceflower (Polygonum multiflorum, also known as He Shou Wu or Fo-Ti) has a long history of use in traditional Chinese medicine (TCM) as a general tonic and for promoting longevity. Among its many traditional uses, it has been employed to help alleviate various types of pain, such as joint pain, muscle aches, and discomfort associated with aging. This use is primarily supported by traditional practices and TCM theory, where it is believed to "nourish the blood," "tonify the liver and kidneys," and thus indirectly address pain, especially pain attributed to deficiencies or imbalances in these organs.

However, scientific evidence specifically validating the use of Chinese Fleeceflower for general pain relief is limited. While some preclinical studies indicate that certain compounds in the plant (such as stilbenes and anthraquinones) may possess anti-inflammatory or antioxidant effects, robust clinical data are lacking. The available research does not directly assess pain reduction in humans, nor does it provide strong mechanistic support for its analgesic effects. As a result, the use of Chinese Fleeceflower for pain remains rooted in tradition, with only modest and indirect support from scientific investigations.

Overall, its use for pain is justified by historical and traditional evidence rather than by high-quality scientific validation. Individuals considering its use should be aware of potential side effects, including liver toxicity, and consult healthcare professionals.