Evidence supporting the use of: Trisodium citrate
For the health condition: Overacidity
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Trisodium citrate is scientifically validated for use in treating overacidity, particularly in the context of metabolic acidosis and certain types of renal tubular acidosis, rather than simple gastric hyperacidity (heartburn). Trisodium citrate acts as a systemic alkalinizing agent: after absorption, it is metabolized in the liver to bicarbonate, which increases blood pH and counteracts acidosis. It is commonly used in clinical settings to manage metabolic acidosis caused by renal failure, diarrhea, or certain poisonings. For example, the World Health Organization includes trisodium citrate in oral rehydration solutions, where it helps correct acidosis in diarrheal diseases.
While trisodium citrate can neutralize gastric acid in vitro, its primary therapeutic value lies in systemic alkalization rather than direct symptomatic relief of gastric hyperacidity. Other agents, such as antacids (e.g., calcium carbonate, magnesium hydroxide), are more commonly used for direct relief of heartburn or indigestion. Nevertheless, the mechanism by which trisodium citrate increases systemic bicarbonate and reduces acid load is well-documented in pharmacological and clinical literature, supporting its use for overacidity at the systemic level.
In summary, the evidence base for trisodium citrate's use in treating systemic overacidity is strong, especially in specific clinical scenarios. However, its use for simple gastric overacidity (heartburn) is less established and not a primary indication.
Other health conditions supported by Trisodium citrate
Acid IndigestionBladder Infection
Kidney Stones
Overacidity
