Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphate salts, such as sodium phosphate and potassium phosphate, are sometimes used in medical settings to manage disturbances in acid-base balance, particularly in cases of metabolic acidosis. Their primary role is as a buffer, helping to neutralize excess acid in the blood. The scientific rationale stems from the phosphate buffer system, which is one of the body's natural mechanisms for maintaining pH balance. However, when it comes to treating overacidity in the stomach (gastric hyperacidity), phosphate salts are not commonly used or recommended as antacids. The principal over-the-counter antacids are compounds like calcium carbonate, magnesium hydroxide, or aluminum hydroxide, which neutralize stomach acid more effectively and with fewer risks.

Some older literature and clinical practices have explored the use of phosphate salts for acid-base disturbances, but robust, modern clinical evidence supporting their use for common gastric overacidity is lacking. Moreover, excessive phosphate intake can lead to side effects, including disturbances in calcium metabolism and kidney function, limiting their use. In summary, while there is a scientific basis for the use of phosphate salts in systemic acid-base regulation, their use as a treatment for gastric overacidity is limited and not supported by strong clinical evidence compared to standard antacids.

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