Aluminum hydroxide is a well-established antacid, widely used in the treatment of overacidity, including conditions such as heartburn, gastritis, and peptic ulcer disease. Its mechanism of action is based on its ability to neutralize gastric hydrochloric acid in the stomach, thereby increasing gastric pH and reducing acidity-related symptoms. The compound reacts with hydrochloric acid to form aluminum chloride and water, temporarily alleviating symptoms of excess stomach acid.

The use of aluminum hydroxide as an antacid is extensively documented in clinical pharmacology and medical guidelines. Numerous randomized controlled trials and decades of clinical use have demonstrated its efficacy in relieving dyspeptic symptoms. It is often formulated in combination with other antacids, such as magnesium hydroxide, to counteract the constipating side effects of aluminum and provide a more balanced effect on gastrointestinal motility.

Major health authorities, including the U.S. Food and Drug Administration (FDA) and the World Health Organization (WHO), list aluminum hydroxide as an approved over-the-counter remedy for hyperacidity. Its use is supported by strong scientific validation and a high level of clinical evidence, reflected in medical textbooks and standard treatment protocols.

While generally safe for short-term use, aluminum hydroxide is not recommended for individuals with renal impairment due to the risk of aluminum accumulation and toxicity. Nevertheless, its role in overacidity management is firmly grounded in scientific evidence.