Evidence supporting the use of: Vitamin D
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is increasingly recognized for its role in reproductive health, including potential effects on ovarian function. Scientific studies have shown that vitamin D receptors are present in ovarian tissue, suggesting physiological relevance. Research indicates that vitamin D may play a role in follicular development, steroidogenesis, and ovulation. For example, some observational studies have found that women with polycystic ovary syndrome (PCOS) often have lower vitamin D levels, and vitamin D supplementation may improve menstrual regularity and metabolic parameters in these women. Additionally, vitamin D deficiency has been associated with infertility and adverse outcomes in assisted reproductive technologies (ART) such as in vitro fertilization (IVF). However, randomized controlled trials evaluating the direct impact of vitamin D supplementation on ovarian function or fertility outcomes are limited and results are mixed.

Overall, there is a growing body of scientific evidence supporting a role for vitamin D in ovarian health, particularly in the context of PCOS and fertility. However, the current evidence is not yet strong enough to universally recommend vitamin D supplementation solely for ovarian support in the absence of deficiency. More rigorous clinical trials are required to clarify the magnitude and mechanisms of these effects.

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