Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin K, particularly in the forms of K1 (phylloquinone) and K2 (menaquinone), has been explored for its role in bone health and the prevention or treatment of osteoporosis. The biological rationale is that vitamin K is an essential cofactor for the carboxylation of osteocalcin, a protein crucial for bone mineralization. Some epidemiological studies have found associations between higher vitamin K intake and increased bone mineral density or reduced fracture risk, particularly in postmenopausal women. Additionally, randomized controlled trials (RCTs), mainly conducted in Japan using high-dose vitamin K2 (menaquinone-4), have shown modest benefits in reducing vertebral fractures, but results are inconsistent and often not replicated in Western populations or with vitamin K1 supplementation.

Systematic reviews and meta-analyses indicate that while vitamin K supplementation may improve biochemical markers of bone health, its impact on actual fracture rates or significant increases in bone mineral density is uncertain. Leading organizations, such as the National Osteoporosis Foundation and International Osteoporosis Foundation, do not currently recommend vitamin K supplementation for osteoporosis prevention or treatment outside of individuals with deficiency or those on long-term anticoagulant therapy (e.g., warfarin). Thus, while there is a scientific rationale and some supportive evidence, the overall quality and consistency of clinical evidence are limited, and routine use is not widely endorsed.

More about vitamin K
More about Osteoporosis

Other ingredients used for Osteoporosis

Other health conditions supported by vitamin K

Products containing vitamin K

Nature's Sunshine Cardio Assurance
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Cardio
Nature's Sunshine VitaWave