Evidence supporting the use of: Vitamin D (mixed)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D is scientifically validated for use in the prevention and management of osteoporosis. Osteoporosis is characterized by decreased bone mass and increased fracture risk. Vitamin D plays a central role in calcium absorption in the gut and maintaining adequate serum calcium and phosphate concentrations, which are necessary for normal bone mineralization. Deficiency in vitamin D can result in impaired bone mineralization, leading to bone softening diseases such as osteomalacia in adults, and it is a significant risk factor for osteoporosis.

Clinical trials and meta-analyses indicate that vitamin D supplementation, especially when combined with calcium, can reduce bone loss and lower the risk of fractures in older adults and populations at risk for deficiency. Guidelines from major health organizations, such as the National Osteoporosis Foundation and the Endocrine Society, recommend vitamin D supplementation for individuals at risk of osteoporosis or those with documented deficiency. While mixed forms of vitamin D (D2 and D3) are available, vitamin D3 (cholecalciferol) is generally considered more effective at raising serum 25(OH)D levels than vitamin D2.

However, vitamin D supplementation alone (without calcium) may have only modest effects on fracture reduction. The evidence is strongest in populations with low baseline vitamin D status or institutionalized elderly. Overall, the use of vitamin D as a part of osteoporosis management is well-supported by scientific evidence.

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