Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in bone remodeling, which has attracted scientific interest in the context of osteoporosis. TGF-β plays a dual role in bone metabolism: it can stimulate the proliferation and differentiation of osteoblasts (bone-forming cells) and regulate osteoclastogenesis (formation of bone-resorbing cells). Preclinical studies in animals and in vitro experiments indicate that TGF-β is essential for maintaining bone mass and structural integrity. Mice with disrupted TGF-β signaling exhibit impaired bone quality and increased bone fragility. Furthermore, TGF-β can modulate the responsiveness of bone to other systemic hormones and cytokines involved in bone turnover. However, evidence for the therapeutic use of TGF-β itself in osteoporosis is limited. While modulating the TGF-β pathway is a subject of ongoing research, there are currently no approved osteoporosis treatments based directly on exogenous TGF-β administration. Some experimental approaches aim to target TGF-β signaling to enhance bone formation or inhibit bone resorption, but these remain in the preclinical or early clinical trial stage. Overall, the scientific rationale exists due to TGF-β’s biological role, but clinical evidence supporting its direct use as a treatment for osteoporosis is weak to moderate at best.

More about Transforming growth factor beta
More about Osteoporosis

Other ingredients used for Osteoporosis

Other health conditions supported by Transforming growth factor beta

Products containing Transforming growth factor beta