Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Strontium, specifically as strontium ranelate, has been studied as a treatment for osteoporosis, particularly in postmenopausal women. The rationale for its use is based on strontium’s chemical similarity to calcium, allowing it to be incorporated into bone and potentially improve bone strength. Clinical trials, such as the SOTI and TROPOS studies, have demonstrated that strontium ranelate can reduce the risk of vertebral and, to a lesser extent, non-vertebral fractures in women with osteoporosis. It appears to have a dual mode of action: both increasing bone formation and decreasing bone resorption.

However, while these studies provided evidence of efficacy, concerns have emerged about the safety of strontium ranelate, particularly regarding increased risks of cardiovascular events, venous thromboembolism, and severe skin reactions. As a result, the use of strontium ranelate has been restricted or withdrawn in some countries, and it is generally recommended only for patients who cannot tolerate other osteoporosis treatments and have no cardiovascular risk factors.

Overall, the evidence supporting the efficacy of strontium ranelate is moderate (hence a rating of 3), but safety concerns limit its use. Over-the-counter strontium supplements (such as strontium citrate) have not been studied with the same rigor, and their safety and efficacy are unclear. In summary, while there is scientific validation for strontium’s benefit in osteoporosis, its clinical use is constrained by safety considerations.

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